Product Details
99% Purity Commercial production DL-4-Chlorophenylalanine methyl ester hydrochloride 14173-40-1 with Cheapest Price
- Molecular Formula: C10H12ClNO2*ClH
- Molecular Weight: 250.125
- Appearance/Colour: white to off-white powder
- Melting Point: 186-189 °C(lit.)
- Boiling Point: 296.3 °C at 760 mmHg
- Flash Point: 133 °C
- PSA： 52.32000
- LogP: 2.88510
DL-4-Chlorophenylalanine methyl ester hydrochloride(Cas 14173-40-1) Usage
|
Biochem/physiol Actions |
Tryptophan hydroxylase inhibitor. Crosses blood brain barrier better than p?chlorophenylalanine. |
|
General Description |
4-Chloro-DL-phenylalanine methyl ester hydrochloride stimulates glucose intolerance in pregnant mice. Studies have shown that 4-Chloro-DL-phenylalanine methyl ester hydrochloride is associated with cognitive defects in rodents. |
InChI:InChI=1/C10H12ClNO2.ClH/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7;/h2-5,9H,6,12H2,1H3;1H/t9-;/m0./s1
14173-40-1 Relevant articles
Beam-induced dehalogenation in LSIMS: Effect of halogen type and matrix chemistry
Theberge,Bertrand
, p. 163 - 171 (1995)
The LSIMS beam-induced dehalogenation of...
The synthesis and characterization of tetramic acid derivatives as Mdm2-p53 inhibitors
Muszak, Damian,?abuzek, Beata,Brela, Mateusz Z.,Twarda-Clapa, Aleksandra,Czub, Miroslawa,Musielak, Bogdan,Surmiak, Ewa,Holak, Tad A.
, p. 161 - 174 (2019/04/26)
We present syntheses, prediction of taut...
Pd-catalyzed dimethylation of tyrosine-derived picolinamide for synthesis of (S)-N-Boc-2,6-dimethyltyrosine and its analogues
Wang, Xuning,Niu, Songtao,Xu, Lanting,Zhang, Chao,Meng, Lingxing,Zhang, Xiaojing,Ma, Dawei
supporting information, p. 246 - 249 (2017/11/27)
A short and efficient synthesis of (S)-N...
Asymmetric chemoenzymatic synthesis of N-acetyl-α-amino esters based on lipase-catalyzed kinetic resolutions through interesterification reactions
Da Silva, Marcos Reinaldo,De Mattos, Marcos Carlos,De Oliveira, Maria Da Concei??o Ferreira,De Lemos, Telma Leda Gomes,Ricardo, Nágila Maria Pontes Silva,De Gonzalo, Gonzalo,Lavandera, Iván,Gotor-Fernández, Vicente,Gotor, Vicente
, p. 2264 - 2271 (2014/03/21)
Several phenylalanine analogs have been ...
Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues
Mollica, Adriano,Feliciani, Federica,Stefanucci, Azzurra,Costante, Roberto,Lucente, Gino,Pinnen, Francesco,Notaristefano, Daniela,Spisani, Susanna
experimental part, p. 418 - 426 (2012/08/28)
In the present study, we report synthesi...
14173-40-1 Process route
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-
182249-59-8
(2S)-2-azido-3-(4-chlorophenyl)propionic acid methyl ester
-
-
14173-40-1,23434-91-5,33965-47-8,60594-65-2
(S)-2-amino-3-(4-chloro-phenyl)-propionic acid methyl ester hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran;
for 4h;
under 760 Torr;
Ambient temperature;
|
-
-
67-56-1
methanol
-
-
14173-39-8,1991-78-2
p-chlorophenylalanine
-
-
14173-40-1,23434-91-5,33965-47-8,60594-65-2
(S)-2-amino-3-(4-chloro-phenyl)-propionic acid methyl ester hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
at 0 ℃;
|
66%
|
|
With
thionyl chloride;
|
|
|
With
thionyl chloride;
at 0 ℃;
|
|
|
With
thionyl chloride;
In
methanol;
Reflux;
|
14173-40-1 Upstream products
-
7424-00-2
DL-Phe(4Cl)
-
67-56-1
methanol
-
6941-36-2
2-acetylamino-2-(4-chlorobenzyl)malonic acid diethyl ester
-
23633-07-0
2-amino-3-(4-chlorophenyl)propionic acid hydrochloride
14173-40-1 Downstream products
-
126376-14-5
DL-3-Amino-4-(4-chlorophenyl)-2-methyl-2-butanol
-
93473-39-3
3-(4-Chloro-phenyl)-2-(dimethylamino-methyleneamino)-propionic acid methyl ester
-
134166-72-6
D-p-chlorophenylalanine methyl ester
-
104907-20-2
1,2-diamino(4-chlorobenzyl)ethane
DL-4-Chlorophenylalanine methyl ester hydrochloride
CAS:14173-40-1
Purity:99%
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